Blood concentrations of endothelin, interleukins 6 and 10 in men with diabetes mellitus

Background. Pathological activation of cytokines is one the key links in pathogenesis diabetes mellitus (DM) and development its complications, particular from cardiovascular system. According to vast majority researchers, imbalance pro- anti-inflammatory patients with a significant risk factor for mortality disease. The purpose study was determine concentration markers nonspecific inflammatory response (interleukin (IL) 6 IL-10) blood men DM their association glycated hemoglobin levels body mass index. Materials methods. There were examined 46 type 2 28 1 DM. results analysis variance control group, had differences some indicators. Results. correlation obtained indicators interleukin showed that under age 50 years, IL-6 significantly positively correlated IL-10 (Spearman’s coefficient 0.562, p<0.031) negatively duration –0.508, p<0.031). In group aged years older, there positive between 0.509, p<0.031), 0.391, p<0.04) 0.551, p<0.005). DM, 0.707, p<0.001) 0.379, p<0.039). Conclusions. Mean elevated older. regardless patients. A found also mellitus.